Extremes of parental age had been associated with psychopathology.
- Having a young (<25 y.o.) or an older father (>30 y.o.) was associated with risk for schizophrenia.
- The increase in risk for younger fathers was limited to male (not female) offspring
- The population attributable risk percentage (PAR%) was 10% for paternal age ≥30 and 5% for paternal age <25. (Miller 2011)
- Younger maternal age is associated with increased risk for ADHD and substance use.
- there is a 78% increased risk for ADHD in youth born to mothers under 20 years of age.
References Miller B. Meta-analysis of paternal age and schizophrenia risk in male versus female offspring. Schizophr Bull. 2011 Sep;37(5):1039-47 Chang Z. Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study. Int J Epidemiol. 2014 Dec;43(6):1815-24.