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==Introduction==
 
Extremes of parental age had been associated with psychopathology.
 
Extremes of parental age had been associated with psychopathology.
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==Autism==
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Advanced age of either parent independently increases the risk for autism spectrum disorders (Durkin 2008)
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* maternal age of 35 years or older adjusted OR= 1.3  (vs. mothers 25-29 years old)
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* paternal age of 40 uears of older adjusted OR = 1.4 (vs. fathers 25-29 years old)
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==Schizophrenia==
  
 
* Having a young (<25 y.o.) or an older father (>30 y.o.) was associated with risk for schizophrenia.
 
* Having a young (<25 y.o.) or an older father (>30 y.o.) was associated with risk for schizophrenia.
 
** The increase in risk for younger fathers was limited to male (not female) offspring
 
** The increase in risk for younger fathers was limited to male (not female) offspring
 
** The population attributable risk percentage (PAR%) was 10% for paternal age ≥30 and 5% for paternal age <25. (Miller 2011)
 
** The population attributable risk percentage (PAR%) was 10% for paternal age ≥30 and 5% for paternal age <25. (Miller 2011)
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== ADHD==
  
 
* Younger maternal age is associated with increased risk for ADHD and substance use.
 
* Younger maternal age is associated with increased risk for ADHD and substance use.
** there is a 78% increased risk for ADHD in youth born to mothers under 20 years of age.
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** there is a 78% increased risk for ADHD in youth born to mothers under 20 years of age. (Chang 2014)
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==References==
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Durkin MS. Advanced parental age and the risk of autism spectrum disorder. Am J Epidemiol. 2008 Dec 1;168(11):1268-76
  
References
 
 
Miller B. Meta-analysis of paternal age and schizophrenia risk in male versus female offspring. Schizophr Bull. 2011 Sep;37(5):1039-47
 
Miller B. Meta-analysis of paternal age and schizophrenia risk in male versus female offspring. Schizophr Bull. 2011 Sep;37(5):1039-47
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Chang Z. Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study. Int J Epidemiol. 2014 Dec;43(6):1815-24.
 
Chang Z. Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study. Int J Epidemiol. 2014 Dec;43(6):1815-24.
  
 
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Revision as of 19:42, 18 May 2017

Introduction

Extremes of parental age had been associated with psychopathology.

Autism

Advanced age of either parent independently increases the risk for autism spectrum disorders (Durkin 2008)

  • maternal age of 35 years or older adjusted OR= 1.3 (vs. mothers 25-29 years old)
  • paternal age of 40 uears of older adjusted OR = 1.4 (vs. fathers 25-29 years old)

Schizophrenia

  • Having a young (<25 y.o.) or an older father (>30 y.o.) was associated with risk for schizophrenia.
    • The increase in risk for younger fathers was limited to male (not female) offspring
    • The population attributable risk percentage (PAR%) was 10% for paternal age ≥30 and 5% for paternal age <25. (Miller 2011)

ADHD

  • Younger maternal age is associated with increased risk for ADHD and substance use.
    • there is a 78% increased risk for ADHD in youth born to mothers under 20 years of age. (Chang 2014)

References

Durkin MS. Advanced parental age and the risk of autism spectrum disorder. Am J Epidemiol. 2008 Dec 1;168(11):1268-76

Miller B. Meta-analysis of paternal age and schizophrenia risk in male versus female offspring. Schizophr Bull. 2011 Sep;37(5):1039-47

Chang Z. Maternal age at childbirth and risk for ADHD in offspring: a population-based cohort study. Int J Epidemiol. 2014 Dec;43(6):1815-24.